Endocrine Abstracts

Introduction: Mct8 is a thyroid hormone specific transporter located at the basolateral plasma membrane of thyrocytes. To investigate the significance of Mct8 to the thyroid gland while excluding peripheral effects observed in global knockout models, we used a Cre-LoxP thyroid-specific Mct8-deficient mouse model. Phenotypes of the angiofollicular unit encompassing the follicle and surrounding endothelial cells were investigated with respect to functional and morphological stat...